Pancreatic cancer-associated diabetes is an "exosomopathy".
نویسنده
چکیده
Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin to β cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer.
منابع مشابه
مروری بر سبب‌شناسی و مارکرهای زیستی دخیل در تشخیص سرطان پانکراس با تاکید بر نقش دیابت در بروز این بیماری: مقاله مروری
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ورودعنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 21 7 شماره
صفحات -
تاریخ انتشار 2015